An RDoC-inspired examination of pharmacological, sex-specific, and hormonal modulators of Positive Valence Systems

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dc.contributor.advisor Demtl, Birgit (Prof. Dr.)
dc.contributor.author Lewis geb. Maier, Carolin Annette
dc.date.accessioned 2023-12-14T16:43:13Z
dc.date.available 2023-12-14T16:43:13Z
dc.date.issued 2023-12-14
dc.identifier.uri http://hdl.handle.net/10900/148718
dc.identifier.uri http://nbn-resolving.de/urn:nbn:de:bsz:21-dspace-1487184 de_DE
dc.identifier.uri http://dx.doi.org/10.15496/publikation-90058
dc.description.abstract The Positive Valence Systems (PVS) are a major domain of the Research Domain Criteria framework (RDoC), which aims at promoting precision medicine for psychiatry, based on a profound understanding of the psychological and biological basis of shared behavioral symptoms. The PVS domain describes basic processes of reward processing, which can be disrupted in several mental disorders, such as schizophrenia, substance use disorders, and major depressive disorder. Investigating basic mechanisms of PVS constructs is important to understand central aspects which contribute to these transdiagnostic motivational syndromes. In my doctoral thesis, I investigated pharmacological, sex-specific, and hormonal modulators of PVS constructs. I focused on the constructs reward responsiveness and reward valuation in the context of motivational behavior in healthy humans. In study 1, I examined the neurotransmitter serotonin, and in particular a selective serotonin reuptake inhibitor (SSRI) as modulator of reward responsiveness on a neural level, using functional magnetic resonance imaging (fMRI). In studies 2 and 3, I inquired into sex-specific and hormonal modulators of reward valuation to elucidate sex-specific integration of benefits and costs on a behavioral level. In study 1, I found that an acute SSRI dose modulated the processing of punishment cues in caudate and thalamus brain regions, which have been identified as transdiagnostic neural markers of disrupted reward responsiveness. In study 2, I identified sex differences in reward valuation, which depended on different encoding of benefits, not costs. Study 3 did not yield substantial differences in reward valuation depending on different hormonal states in women. The RDoC initiative aims at understanding core features and modulators of shared behavioral symptoms, ranging from normal to abnormal behavior. Understanding basic mechanisms is an important first step towards transdiagnostic clinical translation. Within this scope, my work has implications for testing clinical translation of pharmacological and behavioral treatments specifically targeted to PVS constructs, which take sex-specific behavioral variability into account. en
dc.language.iso en de_DE
dc.publisher Universität Tübingen de_DE
dc.rights ubt-podok de_DE
dc.rights.uri http://tobias-lib.uni-tuebingen.de/doku/lic_mit_pod.php?la=de de_DE
dc.rights.uri http://tobias-lib.uni-tuebingen.de/doku/lic_mit_pod.php?la=en en
dc.subject.classification Neurowissenschaften , Psychiatrie , Neuroendokrinologie , Geschlechtsunterschied de_DE
dc.subject.ddc 150 de_DE
dc.subject.ddc 610 de_DE
dc.title An RDoC-inspired examination of pharmacological, sex-specific, and hormonal modulators of Positive Valence Systems en
dc.type PhDThesis de_DE
dcterms.dateAccepted 2023-10-27
utue.publikation.fachbereich Medizin de_DE
utue.publikation.fakultaet 4 Medizinische Fakultät de_DE
utue.publikation.source Lewis, C. A., Mueller, K., Zsido, R., Reinelt, J., Regenthal, R., Okon-Singer, H., Forbes, E. E., Villringer, A., Sacher, J. (2021). A single dose of escitalopram blunts the neural response in the thalamus and caudate during monetary loss. Journal of Psychiatry & Neuroscience 46, S. E319 - E327. /// Lewis, C. A., Grahlow, M., Kühnel, A., Derntl, B., & Kroemer, N. B. (2022, October 28). Women compared with men work harder for small rewards. https://doi.org/10.31234/osf.io/2qs6j /// Lewis, C. A., Kimmig, A.-C. S., Kroemer N. B., Pooseh, S., Smolka, M. N., Sacher, J., Derntl, B. (2022). No Differences in Value-Based Decision- Making Due to Use of Oral Contraceptives. Frontiers in Endocrinology, 13: 817825. de_DE
utue.publikation.noppn yes de_DE

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