ATP-competitive LRRK2 inhibitors interfere with monoclonal antibody binding to the kinase domain of LRRK2 under native conditions. A method to directly monitor the active conformation of LRRK2?

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ATP-competitive LRRK2 inhibitors interfere with monoclonal antibody binding to the kinase domain of LRRK2 under native conditions. A method to directly monitor the active conformation of LRRK2?

Author: Gillardon, Frank; Kremmer, Elisabeth; Froehlich, Thomas; Ueffing, Marius; Hengerer, Bastian; Gloeckner, Christian J.
Tübinger Autor(en):
Ueffing, Marius
Published in: Journal of Neuroscience Methods (2013), Bd. 214, H. 1, S. 62-68
Verlagsangabe: Elsevier Science Bv
Language: English
Full text: http://dx.doi.org/10.1016/j.jneumeth.2012.12.015
ISSN: 0165-0270
DDC Classifikation: 570 - Life sciences; biology
610 - Medicine and health
Dokumentart: Article
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