Exploring Alternative Zinc-Binding Groups in Histone Deacetylase (HDAC) Inhibitors Uncovers DS-103 as a Potent Ethylhydrazide-Based HDAC Inhibitor with Chemosensitizing Properties

Stopper, Daniel; Biermann, Lukas; Watson, Paris R.; Li, Jingyu; Koenig, Beate; Gaynes, Matthew N.; Pessanha de Carvalho, Lais; Klose, Jana; Hanl, Maria; Hamacher, Alexandra; Schaeker-Huebner, Linda; Ramsbeck, Daniel; Held, Jana; Christianson, David W.; Kassack, Matthias U.; Hansen, Finn K.

Exploring Alternative Zinc-Binding Groups in Histone Deacetylase (HDAC) Inhibitors Uncovers DS-103 as a Potent Ethylhydrazide-Based HDAC Inhibitor with Chemosensitizing Properties

Autor(en):

Stopper, Daniel; Biermann, Lukas; Watson, Paris R.; Li, Jingyu; Koenig, Beate; Gaynes, Matthew N.; Pessanha de Carvalho, Lais; Klose, Jana; Hanl, Maria; Hamacher, Alexandra; Schaeker-Huebner, Linda; Ramsbeck, Daniel; Held, Jana; Christianson, David W.; Kassack, Matthias U.; Hansen, Finn K.

Tübinger Autor(en):

Pessanha de Carvalho, Lais
Held, Jana

Erschienen in:

Journal of Medicinal Chemistry (2025), Bd. 68, H. 4, S. 4426-4452

Verlagsangabe:

Washington : Amer Chemical Soc

Sprache:

Englisch

Referenz zum Volltext:

http://dx.doi.org/10.1021/acs.jmedchem.4c02373

ISSN:

0022-2623